How Long before my antibiotic kicks in for a sever infection caused by a toothache? I am currently taking 2000 MG of penicilian and Vicodin for the pain. I went to the er for this. I can barely open my mouth I cant chew and my ear and neck area are all swollen. I have been on the antibiotic for 48 hours and the pain is just as bad as when it started.
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