Migrainous Vertigo: Mutation Analysis of the Candidate

Migrainous Vertigo: Mutation Analysis of the Candidate Genes CACNA1A, ATP1A2, SCN1A, and CACNB4

Michael von Brevern, MD; Nga Ta, BS; Anupama Shankar, MS; AnnaWiste, BS; Anne Siegel, BS; Andrea Radtke, MD; Thomas Sander, MD; Andrew Escayg, PhD

“Background.—Migrainous vertigo (MV) is increasingly recognized as a common cause of episodic vertigo. MV displays several clinical similarities with familial hemiplegic migraine (FHM) and episodic ataxia type 2 (EA-2), which have been linked to mutations in 3 genes, CACNA1A, encoding a neuronal calcium channel α subunit, ATP1A2, encoding a catalytic subunit of a Na+/K±ATPase, and most recently the voltage-gated sodium channel SCN1A. The present study explored the hypothesis that mutations in CACNA1A, ATP1A2, SCN1A, and the calcium channel β4 subunit CACNB4 confer susceptibility to MV.”

mvertigo.org/articles/Migrai … CACNB4.pdf