New Article: A PET study in spontaneous migraine

ncbi.nlm.nih.gov/entrez/quer … query_hl=6

A positron emission tomographic study in spontaneous migraine.

Afridi SK, Giffin NJ, Kaube H, Friston KJ, Ward NS, Frackowiak RS, Goadsby PJ.

Author Affiliations: Headache Group and Wellcome Department of Imaging Neuroscience, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, England.

BACKGROUND: Functional brain imaging in acute migraine has proved challenging because of the logistic problems associated with an episodic condition. Since the seminal observation of brainstem activation in migraine, there has been only a single case substantiating this finding. OBJECTIVE: To test the hypothesis that brainstem activation could be detected in migraine and to refine the anatomic localization with higher-resolution positron emission tomography than previously used. DESIGN: Using positron emission tomography with radioactive water (H(2)(15)O), we studied acute migraine attacks occurring spontaneously. Five patients underwent imaging in ictal and interictal states, and the differences were analyzed by means of statistical parametric mapping. SETTING: Tertiary referral center.Patients Six volunteers with episodic migraine were recruited from advertisements in migraine newsletters. One patient was excluded because of use of preventive medication.Main Outcome Measure Brainstem activation during migraine state vs interictal state. RESULTS: Two patients had a typical migrainous aura before the onset of the headache. All of the attacks studied fulfilled standard diagnostic criteria for migraine. Comparing the migraine scans with interictal scans, there was significant activation in the dorsal pons, lateralized to the left (small volume correction, P = .003). Activation was also seen in the right anterior cingulate, posterior cingulate, cerebellum, thalamus, insula, prefrontal cortex, and temporal lobes. There was an area of deactivation in the migraine phase also located in the pons, lateralized to the right. CONCLUSIONS: Our findings provide clear evidence of dorsal pontine activation in migraine and reinforce the view that migraine is a subcortical disorder modulating afferent neural traffic.

This is an important discovery because parts of the brain affected here… particularly the cerebellum and the pons are the location of the central vestibular neurons.

It could potentially help explain why the vestibular system sometimes becomes involved in migraine - hence a PET scan could say with certainty whether a patient’s central vestibular system was being affected. It’s not practical yet, but maybe one day it will be.