Most neurologists caution against daily nonsteroidals (motrin/aleve) for the potential to cause rebound. Yet, for children, naprosyn is listed as a possible preventive.
So, the jury is out if they can contribute to rebound.
Larry Robbins:
headachedrugs.com/
“Rebound (Withdrawal) Headache
Rebound occurs when a drug is used, or overused, and causes a headache later
on, or the next day. The medicines that contain higher amounts of caffeine (such
as Excedrin) are more likely to induce rebound. This is a murky area, as many
patients are told that they have rebound when it is just their natural headache
pattern. Some people have rebound from small amounts of caffeine, while others
have no rebound from high caffeine doses.
Avariety of meds may cause rebound: Nsaids (Ibuprofen, Advil, Naproxen, Aleve),
Excedrin, Butalbital (Fiorinal, Esgic), Opioids (Vicodin, Codeine), and Triptans
(Imitrex, Maxalt, Zomig, etc.). If a patient usually does not get a headache the 2nd
day, and subsequently has a 2nd day headache after taking a drug, it may be from
that medication. Or some people have 2 days / week of headache, go on a new
abortive med., and within months have daily (or near daily) headaches; we then
think about rebound.
…
The bottom line is: we do not know who gets rebound, and from which drugs. It is
very individual, case by case situation. Practically, what we attempt to do, if
possible, is minimize abortives.”
Then, under first line preventives for migraine:
“5. Naproxen (Naprosyn, Naprelan, Anaprox, Aleve), and other nsaids: Useful in
younger patients, once a day dosing. Sometimes helpful for daily headaches.
Particularly useful for menstrual migraine. Nonsedating, but frequent GI upset.
Effective as an abortive, and may be combined with other first line preventive
medications. The usual dose is 500 or 550 mg. once a day, but this may be
pushed to twice a day. OTC as Aleve. Other anti-inflammatories can be
utilized for prevention of migraine. As with all anti-inflammatories, GI side effects
increase as people age, and so we use these much more in the younger
population.”
Who knows.
I do know my daughter took daily motrin when she was having rough times, and now it’s just the rare dose, and she’s much better. All non-steroidals are hard on stomachs and kidneys.
As we’ve seen, there’s always controversy, even in the same textbook.
Kira